THE INs AND OUTs OF PROTEINS IN THE CONTROL OF CELL FUNCTION
The whole spectrum of proteins within a cell determines its health and function. Proteins are responsible for many tasks of cellular life, including cell shape and inner organization, product synthesis and waste cleanup, and routine maintenance. Proteins also receive signals from outside the cell and orchestrate the intracellular response. Unbalanced production, malfunction or changes in the stability of individual proteins cause pathologies.
Our goal is to understand how proteins function and how they control specific aspects of prokaryotic and eukaryotic cells. We use a multidisciplinary approach encompassing Biochemistry, Structural Biology, Molecular and Cell Biology. We are interested in pinpointing the role of single aminoacids and protein dynamics in controlling ligand binding and kinetics, enzyme activity, protein stability. We are now moving one step ahead, trying to couple basic research to translational studies, in order to identify inhibitors of selected protein targets.
Our recent projects include proteins involved in:
Professor of Molecular Biology
Department of Biochemical Sciences 'A. Rossi Fanelli'.
SAPIENZA University of Rome.
P.le Aldo Moro 5, 00185 - Rome - IT
MONOGRAPHIC ISSUE OF J.BACTERIOLOGY ON CYCLIC-DI-GMP JANUARY 2016
COVER IMAGE (GIORGIO GIARDINA)
Articles from our group in the same issue:
- Cutruzzolà F, Frankenberg-Dinkel N.
Origin and impact of nitric oxide in Pseudomonas aeruginosa biofilms.
-Fernicola S, Paiardini A, Giardina G, Rampioni G, Leoni L, Cutruzzolà F, Rinaldo S.
In silico discovery and in vitro validation of catechol-containing sulfonohydrazide compounds as potent inhibitors of the diguanylate cyclase PleD.